LCH-I - A RANDOMIZED TRIAL OF ETOPOSIDE VS VINBLASTINE IN DISSEMINATED LANGERHANS CELL HISTIOCYTOSIS

Authors
LADISCH S GADNER H ARICO M BROADBENT V GROIS N JACOBSON A KOMP D NICHOLSON HS
Citation
S. Ladisch et al., LCH-I - A RANDOMIZED TRIAL OF ETOPOSIDE VS VINBLASTINE IN DISSEMINATED LANGERHANS CELL HISTIOCYTOSIS, Medical and pediatric oncology, 23(2), 1994, pp. 107-110
Citations number
29
Categorie Soggetti
Oncology,Pediatrics
Journal title
Medical and pediatric oncology → ACNP
ISSN journal
00981532
Volume
23
Issue
2
Year of publication
1994
Pages
107 - 110
Database
ISI
SICI code
0098-1532(1994)23:2<107:L-ARTO>2.0.ZU;2-V
Abstract
An international randomized trial in Langerhans cell histiocytosis (LC H) has been initiated by the Histiocyte Society. This report reviews t he rationale, design, and progress of LCH-I, which compares etoposide (VP-16) and vinblastine in the treatment of disseminated LCH. Data on the risk of etoposide-associated (therapy-induced) malignancy, in the setting of histiocytosis, are reviewed. The available evidence leads t o the recommendation that the study of etoposide in LCH should be cont inued. (C) 1994 Wiley-Liss, Inc.