Previous investigations into the effects of progestins on copulatory b
ehavior have suggested that progesterone inhibits the expression of an
drogen-dependent sexual behaviors in males. However, virtually all of
those studies utilized pharmacological dosages of progesterone. Such e
xperiments, although essential for understanding the behavioral effect
s of progesterone, yield little insight into the function of endogenou
s progesterone in masculine sexual responses. In this brief review, at
tention is focused on the role of physiological levels progesterone in
copulatory behavior in male reptiles and mammals. Efforts are made to
promote a reevaluation of the behavioral effects of progestins in mal
es, similar to ongoing studies which are reexamining neural mechanisms
involved in progestin-mediated reproductive behavior in-the female.