EFFECT OF CHRONIC OPIOID RECEPTOR BLOCKAD E ON INSULIN-RESISTANCE IN A HYPERANDROGENIC WOMAN - REPORT OF ONE CASE

Authors
SIR T LOPEZ G ALBA F CIPRIANO A CANDIA M CASTILLO T DEVOTO L
Citation
T. Sir et al., EFFECT OF CHRONIC OPIOID RECEPTOR BLOCKAD E ON INSULIN-RESISTANCE IN A HYPERANDROGENIC WOMAN - REPORT OF ONE CASE, Revista Medica de Chile, 122(4), 1994, pp. 441-447
Citations number
37
Categorie Soggetti
Medicine, General & Internal
Journal title
Revista Medica de Chile → ACNP
ISSN journal
00349887
Volume
122
Issue
4
Year of publication
1994
Pages
441 - 447
Database
ISI
SICI code
0034-9887(1994)122:4<441:EOCORB>2.0.ZU;2-M
Abstract
We report a woman with insulin resistance associated with hyperandroge nism and acanthosis nigricans (HAIR-AN syndrome) treated during 30 day s with the prolonged action opioid antagonist Naltrexone. During its a dministration, decreases in basal blood glucose and serum insulin, ins ulin and glucose response to a glucose load and plasma testosterone we re observed. These findings suggest that opioid activity could play a critical role in the physiopathology of hyperinsulinemia in hyperandro genic women.