OXYPHILIC SERTOLI-CELL TUMOR OF THE OVARY - A REPORT OF 3 CASES, 2 INPATIENTS WITH THE PEUTZ-JEGHERS SYNDROME

Three women, aged 19, 21, and 30 years, two with the Peutz-Jeghers syn drome (PJS), had unilateral ovarian tumors composed of Sertoli cells w ith abundant eosinophilic cytoplasm. Electron microscopical and immuno histochemical examinations in one case supported the diagnosis of a se x cord tumor. Two patients are well 3 and 20 months postoperatively; t he third was well for 15 years when recurrent tumor involving multiple intraabdominal sites was discovered. The occurrence of two of these t umors in patients with PJS and the known increased frequency of sex co rd tumors in patients with this syndrome indicate an association. Sert oli cell tumor should be included in the differential diagnosis of oxy philic ovarian tumors, particularly if there is a tubular pattern.