GLYCOSYLATION PATTERN OF PLATELET GLYCOPROTEIN IIB AND IIIA IN TYPE IIA HYPERCHOLESTEROLEMIA

The microheterogeneity and polymorphism of platelet membrane glycoprot eins IIb and IIIa from hypercholesterolemic type IIA patients and from normolipidemic controls were compared by isoelectric focusing followe d by immunological detection. Their size and the extent of glycosylati on were investigated by polyacrylamide gel electrophoresis and carbohy drate affinity stain. No qualitative or quantitative differences could be detected, either within each test group or between the two groups. This finding rules out the hypothesis that altered molecular forms of the glycoproteins forming the fibrinogen receptor might be involved i n the pathogenesis of platelet hyperaggregability in hypercholesterole mic patients.