SIMULTANEOUS QUANTITATIVE-DETERMINATION OF TINIDAZOLE AND DILOXANIDE FUROATE IN TABLET PREPARATIONS BY DIFFERENCE SPECTROSCOPY

A difference spectrophotometric procedure has been developed for the s imultaneous determination of Tinidazole (TD) and Diloxanide furoate (D F) in tablet preparations, The method comprised the measurement of abs orbance of a solution of the tablet extract in pH 2.0 buffer solution relative to that of an equimolar solution in pH 13.0 buffer at the wav elengths of 282nm and 240nm. The presence of identical isosbestic poin ts for pure drug samples and tablet extract solutions indicated the no n-interference of excipients in the absorption at these wavelengths. T he compliance of Beer's Law was obtained in the concentration range of 20-40 mu g/ml for TD and DF at these wavelengths.