J. Roy et al., MARKETED VITAMIN-B-COMPLEX INJECTABLES - STABILITY AND MUTUAL INTERACTION, Drug development and industrial pharmacy, 20(13), 1994, pp. 2157-2163
The Vitamin B-complex injectables in the Bangladesh drug market have b
een studied for the sability and mutual interactions of the active ing
redients. It was found that the preparation without nicotinamide in th
e formulation has more stability than that of the preparation having n
icotinamide. The presence of nicotinamide in a formulation containing
four B-vitamins causes the degradation of thiamine to a sub-standard l
evel within one year of the 2 year's shelf-life.