LOW-LEVELS OF AMNIOTIC-FLUID PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN IN DOWNS-SYNDROME

Citation
Aj. Kelly et al., LOW-LEVELS OF AMNIOTIC-FLUID PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN IN DOWNS-SYNDROME, Early human development, 37(3), 1994, pp. 175-178
Citations number
10
Categorie Soggetti
Obsetric & Gynecology",Pediatrics
Journal title
ISSN journal
03783782
Volume
37
Issue
3
Year of publication
1994
Pages
175 - 178
Database
ISI
SICI code
0378-3782(1994)37:3<175:LOAPBI>2.0.ZU;2-F
Abstract
Amniotic fluid levels of beta-1-glycoprotein (SP1) were measured in 46 cases of Down's syndrome and compared with levels in 106 pregnancies of normal karyotype from 10 to 23 weeks of gestation. In normal pregna ncies, levels rose from 87.5 iu/l at 10 weeks to a peak of 610.0 iu/l at 19 weeks of gestation. In cases of Down's syndrome, levels were red uced prior to 19 weeks of gestation (median multiple of the median, Mo M = 0.75, P = 0.02). This effect was most marked prior to 16 weeks of gestation when the median multiple of the median (MoM) was 0.51 (P = 0 .006). These data demonstrate that amniotic fluid levels of SP1 are lo w in Down's syndrome before 19 weeks of gestation.