CONFLUENTIC ACID AND 2'-O-METHYLPERLATOLIC ACID, MONOAMINE-OXIDASE-B INHIBITORS IN A BRAZILIAN PLANT, HIMATANTHUS-SUCUUBA

Authors
ENDO Y HAYASHI H SATO T MARUNO M OHTA T NOZOE S
Citation
Y. Endo et al., CONFLUENTIC ACID AND 2'-O-METHYLPERLATOLIC ACID, MONOAMINE-OXIDASE-B INHIBITORS IN A BRAZILIAN PLANT, HIMATANTHUS-SUCUUBA, Chemical and Pharmaceutical Bulletin, 42(6), 1994, pp. 1198-1201
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
6
Year of publication
1994
Pages
1198 - 1201
Database
ISI
SICI code
0009-2363(1994)42:6<1198:CAA2AM>2.0.ZU;2-6
Abstract
Monoamine oxidase B (MAO-B) inhibitors were isolated from the bark of a Brazilian plant, Himatanthus sucuuba (SPR.). Assignments of the H-1- and C-13-NMR data using two dimensional (2D)-NMR techniques showed th e active components to be known lichen depsides, confluentic acid (1) and 2'-O-methylperlatolic acid (2). The depside (1) showed selective i nhibition of MAO-B with IC50 value of 0.22 mu M.