STOMACHIC PRINCIPLES IN GINGER .3. AN ANTIULCER PRINCIPLE, 6-GINGESULFONIC ACID, AND 3 MONOACYLDIGALACTOSYLGLYCEROLS, GINGERGLYCOLIPID-A, GINGERGLYCOLIPID-B, AND GINGERGLYCOLIPID-C, FROM ZINGIBERIS-RHIZOMA ORIGINATING IN TAIWAN

An anti-ulcer constituent, 6-gingesulfonic acid, and three monoacyldig alactosylglycerols, gingerglycolipids A, B, and C, were isolated from Zingiberis Rhizoma, the dried rhizome of Zingiber officinale ROSCOE wh ich was cultivated in Taiwan, together with (+)-angelicoidenol-2-O-bet a-D-glucopyranoside Based on chemical reactions and physicochemical ev idence, the structures of 6-gingesulfonic acid, gingerglycolipids A, B , and C have been determined. in addition, the absolute stereostructur e of(+)-angelicoidenol-2-O-beta-D-glucopyranoside was clarified on the basis of its synthesis from d-borneol. 6-Gingesulfonic acid showed we aker pungency and more potent anti-ulcer activity than 6-gingerol and 6-shogaol.