PERMEATION OF DICLOFENAC SALTS THROUGH SILICONE MEMBRANE - A MECHANISTIC STUDY OF PERCUTANEOUS-ABSORPTION OF IONIZABLE DRUGS

Authors
MAITANI Y KUGO M NAGAI T
Citation
Y. Maitani et al., PERMEATION OF DICLOFENAC SALTS THROUGH SILICONE MEMBRANE - A MECHANISTIC STUDY OF PERCUTANEOUS-ABSORPTION OF IONIZABLE DRUGS, Chemical and Pharmaceutical Bulletin, 42(6), 1994, pp. 1297-1301
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
6
Year of publication
1994
Pages
1297 - 1301
Database
ISI
SICI code
0009-2363(1994)42:6<1297:PODSTS>2.0.ZU;2-I
Abstract
To understand the mechanism of percutaneous absorption of ionizable dr ugs, diclofenae salts (DM: M=Li, Na, K, NH4, N(Me)(4)) as hydrophilic drugs were compared to free diclofenac acid (DH), a hydrophobic drug. DNa showed the highest permeability coefficient among DMs. The experim ental diffusion coefficient through the silicone membrane (Dm) was com pared with the calculated diffusion coefficient for an ion pair molecu le (Dm(pair)) of DM. This may suggest that the existence of the lipid pathway of the DMs is the same as the DH.