Y. Maitani et al., PERMEATION OF DICLOFENAC SALTS THROUGH SILICONE MEMBRANE - A MECHANISTIC STUDY OF PERCUTANEOUS-ABSORPTION OF IONIZABLE DRUGS, Chemical and Pharmaceutical Bulletin, 42(6), 1994, pp. 1297-1301
To understand the mechanism of percutaneous absorption of ionizable dr
ugs, diclofenae salts (DM: M=Li, Na, K, NH4, N(Me)(4)) as hydrophilic
drugs were compared to free diclofenac acid (DH), a hydrophobic drug.
DNa showed the highest permeability coefficient among DMs. The experim
ental diffusion coefficient through the silicone membrane (Dm) was com
pared with the calculated diffusion coefficient for an ion pair molecu
le (Dm(pair)) of DM. This may suggest that the existence of the lipid
pathway of the DMs is the same as the DH.