MICELLIZATION OF AN AQUEOUS-SOLUTION OF PIPERIDOLATE HYDROCHLORIDE INTHE PRESENCE OF ACETYLCHOLINE CHLORIDE

The surface tension of an aqueous solution of piperidolate hydrochlori de (PIH), which is an anti-cholinergic drug, was measured with a Du No uy tensiometer at 25 degrees C in the absence and presence of acetylch oline chloride (Ach.Cl), and the effect of Ach Cl on the critical mice lle concentration (cmc) of PIH was investigated by comparing it with t he effects of sodium chloride (NaCl) and calcium chloride (CaCl2). Fur thermore, the effect of Ach.Cl on the cmc of PIH was discussed by comp aring it with the effect of Ach.Cl on the cmc of dodecyltrimethylammon ium chloride (DTAC). The value of cmc of PIH decreased with an increas ing concentration of Ach.Cl. The order of the effect on the decrease i n the cmc of PIH was CaCl2 > NaCl > Ach.Cl. The effect of Ach.Cl on th e decrease in the cmc of PIH was smaller than that on the decrease in the cmc of DTAC.