ELATOSIDE-E, A NEW HYPOGLYCEMIC PRINCIPLE FROM THE ROOT CORTEX OF ARALIA-ELATA SEEM - STRUCTURE-RELATED HYPOGLYCEMIC ACTIVITY OLEANOLIC ACID GLYCOSIDES

A new inhibitor named elatosides E (which was shown to affect the elev ation of plasma glucose level by oral sugar tolerance test in rats) wa s isolated from the root cortex of Aralia elata SEEM. together with el atoside F. The structures of elatosides E and F were elucidated on the basis of chemical and physicochemical evidence. The hypoglycemic acti vities of oleanolic acid and nine oleanolic acid glycosides obtained f rom the root cortex of Aralia elata have been examined, and some struc ture-activity relationships have been found.