ECOLOGICAL IMMUNODEFICIENCY - IMMUNOGENET IC ASPECTS OF ITS DEVELOPMENT AND CORRECTION

The examinations of autotransport Kazakh drivers have indicated that t here is a significant reduction in some immunological parameters HLA-B 5 and HLA-DR5-proliferative responses of lymphocytes to mitogens, prod uction of interleukin-1 and interleukin-2, activity of NK and LAK-cell s. It is suggested, that these impairments occur with their long-term exposure to automobile transport effluents (ATE). since the same chang es in immunological parameters were found previously in the experiment s with animals exposed to ATE for a long time. Some of the detected im munoresponsive disorders are associated with the availability of defin ite HLA antigens, such as HLA-B5 and HLA-P5. The new immunomodulating agents thymohexine (TH) and phytoextraction drugs C4 and C6 used in vi tro substantially restored the lower functional activity of immunocomp etent cells and production of cytokines (thymohexine was particularly effective). The most marked recovery was observed in the drivers with the phenotype HLA-B6+ and HLA-P5+, i.e. in persons with maximally ATE- reduced immunological parameters.