[I-125] CGP-42112 REVEALS A NON-ANGIOTENSIN II BINDING-SITE IN 1-METHYL-4-PHENYLPYRIDINE (MPP(-INDUCED BRAIN INJURY()))

Authors
VISWANATHAN M DEOLIVEIRA AM WU RM CHIUEH CC SAAVEDRA JM
Citation
M. Viswanathan et al., [I-125] CGP-42112 REVEALS A NON-ANGIOTENSIN II BINDING-SITE IN 1-METHYL-4-PHENYLPYRIDINE (MPP(-INDUCED BRAIN INJURY())), Cellular and molecular neurobiology, 14(1), 1994, pp. 99-104
Citations number
26
Categorie Soggetti
Neurosciences,"Cytology & Histology",Biology
Journal title
Cellular and molecular neurobiology → ACNP
ISSN journal
02724340
Volume
14
Issue
1
Year of publication
1994
Pages
99 - 104
Database
ISI
SICI code
0272-4340(1994)14:1<99:[CRANI>2.0.ZU;2-F
Abstract
1. Intracerebral injection of the oxidative metabolite of 1-methyl-4-p henyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridine (MP P(+)), into the substantia nigra of adult rats resulted in a lesion at the injection site. 2. Using autoradiography, we localized specific [ I-125]CGP 42112 binding that was not recognized by angiostensin II or angiotensin II AT(1) or AT(2) receptor-selective ligands. 3. Our resul ts suggest that [I-125]CGP 42112 may be binding to activated microglia that appear at the lesion site.