M. Sanz et al., THE EFFECT OF A DENTIFRICE CONTAINING CHLORHEXIDINE AND ZINC ON PLAQUE, GINGIVITIS, CALCULUS AND TOOTH STAINING, Journal of clinical periodontology, 21(6), 1994, pp. 431-437
In this 6 months randomized, stratified double-blind parallel study, p
laque, gingivitis, calculus formation and tooth staining were assessed
in 208 participants. The participants either used a 0.12% chlorhexidi
ne rinse and a gum care dentifrice (positive control) or a placebo rin
se and the gum care dentifrice (control) or the placebo rinse and an e
xperimental dentifrice containing 0.4% chlorhexidine and 0.34% Zn2+ (e
xperimental group). After 6 months product use, all groups had less pl
aque, less gingivitis and all developed calculus and tooth staining. F
or the positive control group and for the experimental group, signific
ant reductions in plaque and gingivitis (gingival index and number of
bleeding sites) were seen compared with the control group. Significant
ly more calculus developed in the positive control group, while the ex
perimental group was not different from the control group. Finally, to
oth staining was significantly higher for the groups using chlorhexidi
ne containing products compared with the control group. The experiment
al dentifrice users however did develop significantly less staining co
mpared with the positive control. It is concluded that the experimenta
l dentifrice will contribute to a significant improvement in oral hygi
ene with less staining compared with using a 0.12% chlorhexidine rinse
.