INTRACELLULAR BACTERICIDAL ACTIVITIES OF CEFPIROME AND MEROPENEM AS COMPARED WITH CIPROFLOXACIN AGAINST SERRATIA-MARCESCENS

Authors
TRAUB WH LEONHARD B BAUER D
Citation
Wh. Traub et al., INTRACELLULAR BACTERICIDAL ACTIVITIES OF CEFPIROME AND MEROPENEM AS COMPARED WITH CIPROFLOXACIN AGAINST SERRATIA-MARCESCENS, Medical microbiology letters, 3(4), 1994, pp. 173-180
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
3
Issue
4
Year of publication
1994
Pages
173 - 180
Database
ISI
SICI code
1018-4627(1994)3:4<173:IBAOCA>2.0.ZU;2-H
Abstract
The addition of phenylbutazone (2 mg/ml) to 55 % (v/v) of fresh defibr inated human blood permitted leukocytic ingestion of serum-resistant S erratia marcescens bacteria, but blocked phagocytic killing activity. A group A (phage tail) bacteriocin of S. marcescens, bA(+) 16, was use d to kill extraphagocytic test bacteria. The fluoroquinolone ciproflox acin rapidly killed ingested bacteria, whereas the cephem cefpirome an d the carbapenem meropenem displayed kinetically delayed intracellular bactericidal activity.