Y. Zhang et al., NON-LINKAGE OF THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR GENE WITH MATURITY-ONSET DIABETES OF THE YOUNG, Diabetologia, 37(7), 1994, pp. 721-724
Citations number
10
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preprogl
ucagon molecule that is secreted by intestinal L cells and stimulates
insulin secretion from betacells. The GLP-1 receptor is a candidate ge
ne for diabetes mellitus, as mutations may induce the impaired insulin
response that is a characteristic feature of NIDDM. To study the rela
tionship between the GLP-1 receptor gene and NIDDM, linkage of a micro
satellite polymorphism flanking the GLP-1 receptor gene with diabetes
was investigated in three Caucasian families with MODY and in the nucl
ear families of 12 NIDDM probands. A cumulative LOD score - 8.50 exclu
des linkage in these MODY pedigrees. A LOD score of - 1.24 in the NIDD
M nuclear pedigrees makes linkage improbable. Mutations in or near the
GLP-1 receptor gene are unlikely to be the major cause of the inherit
ed predisposition to NIDDM in Caucasian pedigrees, but we cannot exclu
de a role for this locus in a polygenic model or a major role in some
pedigrees.