MICROCHEMICAL STRUCTURAL DETERMINATION OF A PEPTOID COVALENTLY BOUND TO A POLYMERIC BY MATRIX-ASSISTED LASER-DESORPTION IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY

Citation
Ra. Zambias et al., MICROCHEMICAL STRUCTURAL DETERMINATION OF A PEPTOID COVALENTLY BOUND TO A POLYMERIC BY MATRIX-ASSISTED LASER-DESORPTION IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY, Tetrahedron letters, 35(25), 1994, pp. 4283-4286
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
35
Issue
25
Year of publication
1994
Pages
4283 - 4286
Database
ISI
SICI code
0040-4039(1994)35:25<4283:MSDOAP>2.0.ZU;2-2
Abstract
New methodology utilizing matrix-assisted laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF MS) for the direct identif ication of a ligand covalently attached to a polymeric bead is reporte d. The method allows for structure determination without relying on en coding strategies. Gaseous TFA cleavage of a peptoid from a single bea d followed by mounting in MALDI matrix and irradiation with a beam at 337 nm gave abundant molecular ions and structurally informative fragm ent ions produced by post source decay (PSD).