2,2'-BIS(2-AMINOETHYL)-4,4'-BITHIAZOLE SYNTHESIS OF A NOVEL DNA-CLEAVING AGENT ACTIVATED BY CO(II)

Authors
SASAKI H
Citation
H. Sasaki, 2,2'-BIS(2-AMINOETHYL)-4,4'-BITHIAZOLE SYNTHESIS OF A NOVEL DNA-CLEAVING AGENT ACTIVATED BY CO(II), Tetrahedron letters, 35(25), 1994, pp. 4401-4404
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
25
Year of publication
1994
Pages
4401 - 4404
Database
ISI
SICI code
0040-4039(1994)35:25<4401:2SOAND>2.0.ZU;2-Q
Abstract
A novel DNA cleaving agent 2,2'-bis(2-aminoethyl)-4,4'-bithiazole (1) was synthesized. Only in the presence of Co(II), a significant cleavin g activity of 1 for plasmid DNA was observed at 10 mu M concentration. Some inhibition reactions indicated that scavengers of hydroxyl radic al and singlet oxygen, superoxide dismutase, and catalase could not af fect the present DNA cleavage.