SYNTHESIS OF COMBRETASTATIN D-2 - AN EFFICIENT ROUTE TO CAFFRANE MACROLACTONES

Authors
COULADOUROS EA SOUFLI IC
Citation
Ea. Couladouros et Ic. Soufli, SYNTHESIS OF COMBRETASTATIN D-2 - AN EFFICIENT ROUTE TO CAFFRANE MACROLACTONES, Tetrahedron letters, 35(25), 1994, pp. 4409-4412
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
25
Year of publication
1994
Pages
4409 - 4412
Database
ISI
SICI code
0040-4039(1994)35:25<4409:SOCD-A>2.0.ZU;2-3
Abstract
Combretastatin D-2, (1), was synthesized via a 10 step sequence. Macro lactonization was performed on saturated substrate 12 in high yield an d the double bond was established via dehalogenation of intermediate 1 5.