STEPWISE SOLID-PHASE SYNTHESIS OF NUCLEOPEPTIDE PHAC-SER(P(5')CATCAT)-GLY-ASP-OH FROM ADENOVIRUS-2 NUCLEOPROTEIN

Citation
J. Robles et al., STEPWISE SOLID-PHASE SYNTHESIS OF NUCLEOPEPTIDE PHAC-SER(P(5')CATCAT)-GLY-ASP-OH FROM ADENOVIRUS-2 NUCLEOPROTEIN, Tetrahedron letters, 35(25), 1994, pp. 4449-4452
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
35
Issue
25
Year of publication
1994
Pages
4449 - 4452
Database
ISI
SICI code
0040-4039(1994)35:25<4449:SSSONP>2.0.ZU;2-9
Abstract
Nucleopeptide Phac-Ser(p(5')CATCAT)-Gly-Asp-OH, corresponding to the l inking site of adenovirus-2 nucleoprotein, has been synthesised by a s tepwise solid-phase methodology. After assembly of the peptide on a so lid support, the oligonucleotide chain elongation was carried out at t he hydroxyl group of the serine residue by the phosphite triester appr oach using 5'-phosphoramidite derivatives. The target nucleopeptide wa s then obtained in good yield after removal of the permanent protectin g groups under mild basic conditions.