STEPWISE SOLID-PHASE SYNTHESIS OF NUCLEOPEPTIDE PHAC-SER(P(5')CATCAT)-GLY-ASP-OH FROM ADENOVIRUS-2 NUCLEOPROTEIN

Nucleopeptide Phac-Ser(p(5')CATCAT)-Gly-Asp-OH, corresponding to the l inking site of adenovirus-2 nucleoprotein, has been synthesised by a s tepwise solid-phase methodology. After assembly of the peptide on a so lid support, the oligonucleotide chain elongation was carried out at t he hydroxyl group of the serine residue by the phosphite triester appr oach using 5'-phosphoramidite derivatives. The target nucleopeptide wa s then obtained in good yield after removal of the permanent protectin g groups under mild basic conditions.