J. Robles et al., STEPWISE SOLID-PHASE SYNTHESIS OF NUCLEOPEPTIDE PHAC-SER(P(5')CATCAT)-GLY-ASP-OH FROM ADENOVIRUS-2 NUCLEOPROTEIN, Tetrahedron letters, 35(25), 1994, pp. 4449-4452
Nucleopeptide Phac-Ser(p(5')CATCAT)-Gly-Asp-OH, corresponding to the l
inking site of adenovirus-2 nucleoprotein, has been synthesised by a s
tepwise solid-phase methodology. After assembly of the peptide on a so
lid support, the oligonucleotide chain elongation was carried out at t
he hydroxyl group of the serine residue by the phosphite triester appr
oach using 5'-phosphoramidite derivatives. The target nucleopeptide wa
s then obtained in good yield after removal of the permanent protectin
g groups under mild basic conditions.