C-TYPE NATRIURETIC PEPTIDE INCREASES CYCLIC-GMP IN RAT CEREBRAL MICROVESSELS IN PRIMARY CULTURE

Authors
KOBAYASHI H UENO S TSUTSUI M OKAZAKI M UEZONO Y YANAGIHARA N YUHI T IZUMI F
Citation
H. Kobayashi et al., C-TYPE NATRIURETIC PEPTIDE INCREASES CYCLIC-GMP IN RAT CEREBRAL MICROVESSELS IN PRIMARY CULTURE, Brain research, 648(2), 1994, pp. 324-326
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
648
Issue
2
Year of publication
1994
Pages
324 - 326
Database
ISI
SICI code
0006-8993(1994)648:2<324:CNPICI>2.0.ZU;2-V
Abstract
Effect of CNP on cGMP level in cultured rat cerebral microvessels was investigated. The cerebral microvessels were prepared from rat cerebra l cortex by dispase and collagenase digestion and Percoll gradient cen trifugation, and cultured. CNP increased cGMP level in a dose-dependen t manner suggesting that CNP has a regulatory role in the cerebral mic rovessel function.