IMMUNOSUPPRESSANTS AND CALCINEURIN INHIBITORS, CYCLOSPORINE-A AND FK506, REVERSIBLY INHIBIT EPILEPTOGENESIS IN AMYGDALOID-KINDLED RAT

Authors
MOIA LJMP MATSUI H DEBARROS GAM TOMIZAWA K MIYAMOTO K KUWATA Y TOKUDA M ITANO T HATASE O
Citation
Ljmp. Moia et al., IMMUNOSUPPRESSANTS AND CALCINEURIN INHIBITORS, CYCLOSPORINE-A AND FK506, REVERSIBLY INHIBIT EPILEPTOGENESIS IN AMYGDALOID-KINDLED RAT, Brain research, 648(2), 1994, pp. 337-341
Citations number
29
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
648
Issue
2
Year of publication
1994
Pages
337 - 341
Database
ISI
SICI code
0006-8993(1994)648:2<337:IACICA>2.0.ZU;2-L
Abstract
Calcineurin (CaN) immunoreactivity and content increased markedly in k indled rat brain, and this increment was due to CaN in the membrane fr action. Investigation of the effects of cyclosporin A and FK506 (immun osuppressants which inhibit CaN activity in T lymphocytes) in the kind ling phenomena showed that the kindling stage progression was reversib ly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.