EVALUATION OF URINARY ENZYMES IN DOGS WITH EARLY RENAL DISORDER

We investigated urinary N-acetyl-beta-D-glucosaminidase NAG (EC 3.2.1. 30), gamma-glutamyl transpeptidase gamma-GTP (EC 2.3.2.2) and glycyl-p rolyl dipeptidyl aminopeptidase GP-DAP (EC 3. 4.14.5) in dogs with hea rtworm disease and renal failure. In the renal failure dogs, the NAG, gamma-GTP and GP-DAP index were significantly higher than those in the healthy dogs. In the heartworm disease dogs with normal chest X-rays (HW I), none of the enzyme values was significantly different from tho se of the healthy controls, In the dogs with heartworm disease showing abnormal heart shadows on their chest X-rays (HW II), enzyme values w ere significantly higher than those in the healthy dogs (P<0.01) and t he HW I dogs (P<0.01). Thus. these urinary enzymes tests are available for the early detection of renal disorders.