SIMPLIFICATION OF SUPEROVULATION INDUCTION BY USING POLYVINYLPYRROLIDONE AS A SOLVENT FOR FSH IN RABBITS

With a view to simplify the method of inducing superovulation in rabbi ts, polyvinvlpyrrolidone (PVP) was used as a solvent for follicle-stim ulating hormone (FSH). As a result, it became clear that more than the equivalent number of ovulation points and fertilized ova that are obt ainable by the conventional six injections of FSH were able to be obta ined by only a single injection of FSH-PVP preparation. Inflammation o r swelling of the tissue was not observed in the injection site or its vicinity. The results seem to enable simplification of superovulation induction by using PVP as a vehicle for FSH in rabbits. This finding could reduce injection distress to the animals and labor of the operat or.