M. Fukata et al., ALTERATIONS OF METAL CONTENT IN THE KIDNEYS OF PUROMYCIN AMINONUCLEOSIDE-ADMINISTERED RATS, Biological & pharmaceutical bulletin, 17(6), 1994, pp. 871-873
To explore the mechanism responsible for puromycin aminonucleoside ind
uced-nephrotoxicity, metal content was preliminarily investigated in t
he kidneys of rats that had received a single subcutaneous injection o
f the agent (80 mg/kg body weight). In the group that received this ag
ent, the renal content of Fe rose on days 5, 10, and 15; that of Cu fe
ll on days 10 and 15; that of Zn rose on day 5; that of Se fell on day
10; there were no changes in Mn throughout the experimental period. P
roviding that these findings directly involved the renal activities of
superoxide dismutases and glutathione peroxidase, the renal reduction
of Cu and Se gave proof counter to previous findings of an enzymatic
protective system against possible attacks by the oxygen radicals.