FRENCH IVF REGISTRY FIVNAT - 1993 REPORT

FIVNAT registry collected information on 24,921 individual assisted re productive technology (ART) cycles in 1993 and the present analysis co ncerns 17,102 cycles arrived on time to be incorporated, 96.5 % being in vitro fertilization (IVF) cycles. The positive ponction rate for IV F (98.5 %) and the transfer rate (80.1 %) were not modified. The clini cal pregnancy rates progressed to 20.4 % per oocyte recovery cycle and to 25.5 % per transfer, they were clearly increasing from 1992. The m ean oocyte number (8.8 +/- 5.5) and the mean embryo number (4.02 +/- 3 .81) were slightly increasing, but the mean number of transferred embr yos was not modified (2.73 +/- 1.09). That confirms the transfer strat egy of clinics. In 1993, the proportion of infertilities of tubal orig in decreased (56,6 % vs 58.9 in 1992), and those of male origin increa sed (37.5 % vs 32.6 % in 1992). The pregnancy rate increased for all t he indications, especially for cycles realised with donor semen, excep t for the immunological one. Most of the stimulation regimen used the GnRH analogues protocols with a long bloc-king period (73.5 %) : they obtained the highest pregnancy rate per transferred embryo (24.6 %). A n increasing proportion of transfers involving 3 embryos was notified (39.1 % vs 379 % in 1992); the clinical pregnancy rates per transferre d embryo were increasing since the last two years for transfers involv ing one to three embryos. The analysis of 11 405 clinical pregnancies resulting from recoveries realised between 1986 and 1992 showed a pret erm birth rate of 9.3 % for singleton, but a still high rate for twins and multiple pregnancies. For singleton pregnancies, in utero mortali ty concerned 5.6 parts per thousand of the children, and the neonatal mortality rate (< 7 days) was 5.4 parts per thousand. The overall malf ormation rate was 2.8 %.