RELATION BETWEEN CYTOKINES AND ROUTINE LABORATORY DATA IN CHILDREN WITH SEPTIC SHOCK AND PURPURA

Objective: To establish the relation between routine laboratory data ( lactate, fibrinogen, CRP) and cytokines (TNF,IL - 1 and - 6) and to es timate their prognostic value in pediatric patients with severe infect ious purpura on admission. Design: Prospective study. Setting: Pediatr ic intensive care unit (PICU). Patients: 17 children aged 5-172 months (median 46) were hospitalized in our PICU in 1989-90 with severe infe ctious purpura. Neisseria meningitidis was isolated in 15 children and Haemophilus influenzae in two. The patients were divided into 3 group s: non-shock, shock and severe shock leading to death. Shock was defin ed by standard criteria. Measurements. Arterial blood was sampled for lactate, CRP, fibrinogen, TNF, and IL-1 and -6 on admission. The PRISM (pediatric risk of morality)-score was recorded. Methods. Statistical analysis was performed with the Student's t-test using the logarithmi c values of the cytokine concentration, and Spearman correlation analy sis. Results. According to the shock criteria, 9 patients were in shoc k of whom 4 did not survive. Significant differences existed between t he 3 groups concerning lactate, TNF, and IL-6. Fibrinogen, CRP, IL-1, and PRISM-score discriminated only between survivors and non-survivors . A highly significant correlation existed between cytokines, the PRIS M-score and lactate (TNF: r = 0.69, IL-1: r = 0.56, IL,6: r = 0.65, PR ISM: r = 0.65). A significant inverse correlation existed between cyto kines and CRP (TNF: r = -0.55, IL-1: r = -0.64, and IL-6: r = -0.56), and IL-6 and fibrinogen (r = -0.65). Conclusion: These results show a significant correlation between cytokines and lactate, and lactate, TN F and IL-6 are closely associated with the severity of septic shock wi th purpura in children.