THE APPLICATION OF TOPOLOGICAL INDEXES (IT) FOR PREDICTION OF THE RM VALUES OF ISOMERIC ALCOHOLS .5.

Selected aromatic alcohols have been separated by TLC and correlations sought between R(M), the partition coefficient, log P, calculated usi ng Rekker fragmental constants, and the numerical values of the topolo gical indexes M, 0X(v), 1X(v), 2X(v), 3X(v), W, I(B), A, 0B, 1B, 2B, B -2(q), 3B, B-3(q), C, D, and X012. Many correlation coefficients (r > 0.99) were indicative of high correlation, enabling prediction of R(M) , log P, and numerical values of topological indexes for the alcohols investigated. By suitable transformation of the equations obtained it was possible to derive new correlation equations enabling the calculat ion of numerical values of topological indexes which could be used in the formulation of rules for analytical identification of the compound s studied.