SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC SODIUM IN PHARMACEUTICAL PREPARATIONS BY QUANTITATIVE TLC

Authors
SHINDE VM TENDOLKAR NM DESAI BS
Citation
Vm. Shinde et al., SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC SODIUM IN PHARMACEUTICAL PREPARATIONS BY QUANTITATIVE TLC, JPC. Journal of planar chromatography, modern TLC, 7(1), 1994, pp. 50-53
Citations number
35
Categorie Soggetti
Chemistry Analytical
Journal title
JPC. Journal of planar chromatography, modern TLC → ACNP
ISSN journal
09334173
Volume
7
Issue
1
Year of publication
1994
Pages
50 - 53
Database
ISI
SICI code
0933-4173(1994)7:1<50:SDOPAD>2.0.ZU;2-F
Abstract
A simple, precise, and rapid HPTLC method has been developed for simul taneous determination of Paracetamol and Diclofenac Sodium in pharmace utical preparations. Chromatography on silica gel plates developed wit h chloroform - methanol - ammonia (10 + 2.5 + 0.1, v/v) results in a l inear response in the concentration range 100-600 ng for Paracetamol a nd 10-60 ng for Diclofenac Sodium. The standard deviation for Paraceta mol and Diclofenac Sodium is 0.731 and 1.722%, respectively, and the r ecovery of the compounds is 97.4% and 99.84%, respectively.