ASYMMETRIC-SYNTHESIS AND REACTIONS OF CIS-N-(P-TOLUENESULFINYL)AZIRIDINE-2-CARBOXYLIC ACIDS

Authors
DAVIS FA ZHOU P REDDY GV
Citation
Fa. Davis et al., ASYMMETRIC-SYNTHESIS AND REACTIONS OF CIS-N-(P-TOLUENESULFINYL)AZIRIDINE-2-CARBOXYLIC ACIDS, Journal of organic chemistry, 59(12), 1994, pp. 3243-3245
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
12
Year of publication
1994
Pages
3243 - 3245
Database
ISI
SICI code
0022-3263(1994)59:12<3243:AAROC>2.0.ZU;2-7
Abstract
cis-Aziridine-2-carboxylic acids, 2, precursors of the difficult to pr epare syn-beta-hydroxy-alpha-amino acid structural unit, are prepared in high diastereomeric purity by a Darzens-type reaction of the lithiu m enolate of methyl bromoacetate with enantiopure sulfinimines 1.