BALHIMYCIN, A NEW GLYCOPEPTIDE ANTIBIOTIC WITH AN UNUSUAL HYDRATED 3-AMINO-4-OXOALDOPYRANOSE SUGAR MOIETY

Balbimycin (1), C66H73Cl2N9O24, is a new glycopeptide antibiotic of th e vancomycin class. It was isolated from the fermentation broth of an Amycolatopsis sp. Hoechst India Limited Y-86,21022. Its structure was elucidated on the basis of spectroscopic and chemical degradation stud ies. The aglycon is identical to that of vancomycin. The molecule cont ains two sugars, D-glucose and dehydrovancosamine. The latter unit rem ains as a hydrate in solution.