ANTIINFLAMMATORY ACTIVITY OF LEAF EXTRACTS OF EUGENIA-JAMBOS IN RATS

The anti-inflammatory activities of four organic extracts from the lea ves of Eugenia jambos were investigated in rats using the Mizushima et al, model of acute and chronic inflammation (Mizushima ct al. (1972) Journal of Pharmacy and Pharmacology 24, 781-785). Orally administered organic extracts of E. jambos (hexane, dichloromethane, ethyl acetate and methanol), given at daily doses equivalent to 12.5 g/kg of dried leaf material, inhibited both the acute and chronic phases of this exp erimental model of inflammation. The ethyl acetate and methanol extrac ts were the most effective and were equal or more effective than 80 mg /kg of phenylbutazone. The methanolic extract was the most active in t he chronic phase. A 10% aqueous extract (infusion) of the leaves teste d in the same model was more effective than all of the organic extract s.