FAMILIAL ADENOMATOUS POLYPOSIS AND THYROI D-CARCINOMA

Familial adenomatous polyposis may exhibit extracolonic tumors which i nclude thyroid carcinoma. It has been recently suggested that thyroid carcinomas associated with familial adenomatous polyposis show distinc t histologic features different from sporadic follicular or papillary thyroid carcinomas. We report a case of thyroid carcinoma in a young g irl affected by familial adenomatous polyposis, whose thyroid tumor ex hibited some of these features. This finding confirms the peculiar his tologic phenotype of the thyroid carcinomas associated with familial a denomatous polyposis. Alterations of the APC gene responsible for fami lial adenomatous polyposis may play a role in the development of these thyroid cancers.