ONCE-DAILY ANTIBIOTIC REGIMEN IN PEDIATRIC ONCOLOGY

The feasibility and efficacy of a once daily antibiotic regimen were a ssessed in children with malignant tumours. Over a 44 month period, 29 6 febrile episodes were treated with a regimen of once daily ceftriaxo ne-amikacin (and teicoplanin or vancomycin if the patient had a centra l Line). The treatment was successful in 272 (92%) episodes without mo dification of tile antibiotic regimen, and only one patient died of un controlled sepsis. A once daily antibiotic regimen is therefore feasib le and worthwhile in the treatment of febrile episodes in children wit h cancer.