TISSUE INSULIN CONTENTS IN NESIDIOBLASTOSIS - REPORT OF 2 CASES

We present two cases of nesidioblastosis, a common cause of persistent hypoglycemia in infancy that, if inadequately treated, can lead to me ntal retardation. Tissue insulin data obtained from both radioimmunoas say and immunohistochemistry are presented. In each case, the insulin content correlated well with the quantity of insulin-positive cells in each portion of the pancreas. However, the insulin content varied fro m case to case and from portion to portion of the same pancreas. Thus, discrepancies in clinical results in nesidioblastosis may be due to v ariability of insulin content in the resected pancreas.