ORAL RETENTION OF GLUCOSE AT PHARMACOLOGICALLY REDUCED SALIVARY FLOW IN MAN

The aim was to study the influence of mouthrinses with glucose, at con centrations ranging from 1 to 50%, on oral retention at two different locations in the oral cavity. Salivary secretion was reduced in 10 sub jects by injection of methylscopolamine nitrate submucosally. The volu nteers were randomly assigned to rinse with 10 ml of either 1%, 10%, o r 50% glucose solution for 30 s, after which measurements of glucose c oncentration and parotid salivary secretion rate were performed during a 10-min period. The results showed higher salivary glucose levels ve stibularly than sublingually. The difference in glucose retention betw een the two locations increased when the salivary flow rate recovered. The relationship between secretion rate and area under the curve for glucose measured sublingually, but not in the vestibule, was bilinear.