The effects of 6 months of muscle training with an inspiratory pressur
e load equal to 30% of the maximal inspiratory pressure (PI(max)) was
compared with sham training with a light inspiratory pressure load. In
this double-blind randomly assigned study, 67 patients with chronic o
bstructive pulmonary disease were followed for 6 months. Both groups d
emonstrated improvements in performance of PI(max), respiratory muscle
endurance time for breathing against an inspiratory pressure load equ
al to 66% of PI(max), 12-minute distance walk, and dyspnea. The treatm
ent group did not demonstrate significant effects beyond those observe
d in the control group. Improvements in performance were related to im
proved coordination of the inspiratory muscles and desensitization to
dyspnea.