We examined the relation between recent cocaine use and heterosexual e
xposure to human immunodeficiency virus (HIV). Five hundred nineteen h
eterosexually active participants in the New England Behavioral Health
Study, an HN resting and counseling program, provided information for
this study. The outcome measure included behaviors that increased the
risk for exposure to HIV via contact with infected genital secretions
. Nearly one third (31.8%) of participants reported use of cocaine dur
ing the year before study entry. These individuals were 1.3 times [90%
confidence interval (CI) = 1.1-1.7] more likely to risk HIV exposure
than people not using cocaine during this period, with evidence of a d
ose dependent relation among HN positive cocaine users. HIV positive c
rack users were at 1.9 times greater risk (90% CI = 2.2-2.9) for HIV r
isk taking behavior than those who did not use crack. The effect of co
caine was present even among those individuals without other injection
drug use.