CYTOGENETIC STUDIES ON PATIENTS OF ACUTE LYMPHOBLASTIC-LEUKEMIA BURKITT TYPE WITH (8,14)-TRANSLOCATION AND (14,18)-TRANSLOCATION

Authors
GLADSTONE B KADAM PR BALSARA BR PAI SK GOPAL R NAIR CN PARIKH PM ADVANI SH SAIKIA T
Citation
B. Gladstone et al., CYTOGENETIC STUDIES ON PATIENTS OF ACUTE LYMPHOBLASTIC-LEUKEMIA BURKITT TYPE WITH (8,14)-TRANSLOCATION AND (14,18)-TRANSLOCATION, INDIAN JOURNAL OF MEDICAL RESEARCH, 99, 1994, pp. 264-266
Citations number
13
Categorie Soggetti
Medicine, General & Internal",Immunology
Journal title
INDIAN JOURNAL OF MEDICAL RESEARCH → ACNP
ISSN journal
09715916
Volume
99
Year of publication
1994
Pages
264 - 266
Database
ISI
SICI code
0971-5916(1994)99:<264:CSOPOA>2.0.ZU;2-1
Abstract
Eight patients with acute lymphoblastic leukemia of Burkitt's type (AL L-L3) and two patients with Burkitt's lymphoma (BL) were subjected for cytogenetic studies. Translocation (8;14)(q24;q32) was present in nin e (90%) patients; seven patients of ALL-L3 and two of BL. One ALL-L3 p atient revealed; t(14;18)(q32;q21) in 100 per cent metaphases. Additio nal clonal chromosomal anomalies present in these patients were deleti on (6q) (40%) and trisomy 21(20%). The occurrence of t(8;14)(q24;q32) in ALL-L3 and BL patients in our series supports the association of t( 8;14) with ALL-L3 and Burkitt's lymphoma.