T-CELLS AS ANTIGEN-PRESENTING CELLS

Citation
Wj. Pichler et T. Wysscoray, T-CELLS AS ANTIGEN-PRESENTING CELLS, Immunology today, 15(7), 1994, pp. 312-315
Citations number
40
Categorie Soggetti
Immunology
Journal title
ISSN journal
01675699
Volume
15
Issue
7
Year of publication
1994
Pages
312 - 315
Database
ISI
SICI code
0167-5699(1994)15:7<312:TAAC>2.0.ZU;2-N
Abstract
Human T cells express major histocompatibility complex (MHC) class II antigens and adhesion molecules characteristic of antigen-presenting c ells (APCs), and recent in vitro and in vivo evidence supports an anti gen-presenting function for T cells. In this guise, T cells provide do wnregulatory signals for the immune response by inducing anergy in T c ells that have already been activated and cytotoxicity in resting T ce lls. Here, Werner Pichler and Tony Wyss-Coray suggest that this may re present art important negative mechanism for T-cell homeostasis.