INHIBITORY EFFECT OF VAPIPROST ON CONTRACTILE RESPONSES OF ISOLATED DOG RENAL-ARTERIES TO THROMBOXANE A(2) ANALOG, U46619

Authors
SAKANASHI M MATSUZAKI T NOGUCHI K NAKASONE J ITOMINE T UZA M TOYAMA F HIGUCHI M
Citation
M. Sakanashi et al., INHIBITORY EFFECT OF VAPIPROST ON CONTRACTILE RESPONSES OF ISOLATED DOG RENAL-ARTERIES TO THROMBOXANE A(2) ANALOG, U46619, General pharmacology, 25(4), 1994, pp. 617-622
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
25
Issue
4
Year of publication
1994
Pages
617 - 622
Database
ISI
SICI code
0306-3623(1994)25:4<617:IEOVOC>2.0.ZU;2-U
Abstract
1. Cumulative administrations of U46619, a thromboxane A(2) analogue, and prostaglandin (PG) F-2 alpha produced concentration-dependent cont ractions of isolated dog renal arterial preparations, which were signi ficantly and concentration-dependently inhibited by vapiprost. 2. A bo lus administration of U46619 or PGF(2 alpha) produced sustained contra cture of these preparations, which was concentration-dependently relax ed by cumulative vapiprost. 3. Results indicate that vapiprost inhibit s U46619- and PGF2 alpha-induced dog renal arterial contractions throu gh antagonism for so-called TP receptors.