M. Shimabukuro et al., CHRONIC GLICLAZIDE TREATMENT AFFECTS BASAL AND POSTISCHEMIC CARDIAC-FUNCTION IN DIABETIC RATS, General pharmacology, 25(4), 1994, pp. 697-704
1. A 6-week gliclazide treatment improved left ventricular developed p
ressure and left ventricular end-diastolic pressure, left ventricular
pressure-rate products in isolated working hearts from streptozotocin-
induced diabetic rats. 2. Post-ischemic recovery in heart rate, left v
entricular developed pressure, left Ventricular end-diastolic pressure
, left ventricular pressure-rate products and cardiac work were also s
hown in gliclazide-treated diabetic rats. 3. Gliclazide treatment did
not modify the degree of insulinopenia and hyperglycaemia, nor the myo
cardial energy metabolism during ischemia-reperfusion. 4. The results
suggest that the gliclazide treatment has a cardioprotective effect on
basal and post-ischemic cardiac functions of chronic diabetes.