COMPARATIVE EFFECTS OF THE DIHYDROPYRIDINE-TYPE CALCIUM-AGONISTS (-)-S-BAY-K-8644, (+ -)-BAY-W-5035 AND (+/-)-BAY-T-5006 ON HUMAN PLATELET AGGREGABILITY/

Authors
RUMP AFE BOLLER M BERKELS R ROSEN R FRICKE U KLAUS W
Citation
Afe. Rump et al., COMPARATIVE EFFECTS OF THE DIHYDROPYRIDINE-TYPE CALCIUM-AGONISTS (-)-S-BAY-K-8644, (+ -)-BAY-W-5035 AND (+/-)-BAY-T-5006 ON HUMAN PLATELET AGGREGABILITY/, General pharmacology, 25(3), 1994, pp. 447-450
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
25
Issue
3
Year of publication
1994
Pages
447 - 450
Database
ISI
SICI code
0306-3623(1994)25:3<447:CEOTDC>2.0.ZU;2-A
Abstract
1. Human platelet aggregation induced by collagen is concentration-dep endently inhibited by dihydropyridine (DHP)-type calcium(Ca)-agonists. 2. There was no significant difference between the maximal anti-aggre gatory effects or the antiaggregatory potencies of (-)-S-Bay-K 8644 (E C(50): 5.3 +/- 1.5 x 10(-5) M), (+/-)-Bay-W 5035 (EC(50): 14.9 +/- 8.8 x 10(-5) M) or (+/-)-Bay-T 5006 (EC(50): 2.7 +/- 1.9 x 10(-5) M) (P > 0.05). 3. Antiaggregatory effects of DHP-type Ca-agonists seem to be independent of Ca-channel activation.