A SYSTEMATIC-APPROACH FOR EVALUATING THE QUALITY OF EXPERIMENTAL TOXICOLOGICAL AND ECOTOXICOLOGICAL DATA

Authors
KLIMISCH HJ ANDREAE M TILLMANN U
Citation
Hj. Klimisch et al., A SYSTEMATIC-APPROACH FOR EVALUATING THE QUALITY OF EXPERIMENTAL TOXICOLOGICAL AND ECOTOXICOLOGICAL DATA, Regulatory toxicology and pharmacology, 25(1), 1997, pp. 1-5
Citations number
5
Categorie Soggetti
Medicine, Legal","Pharmacology & Pharmacy",Toxicology
Journal title
Regulatory toxicology and pharmacology → ACNP
ISSN journal
02732300
Volume
25
Issue
1
Year of publication
1997
Pages
1 - 5
Database
ISI
SICI code
0273-2300(1997)25:1<1:ASFETQ>2.0.ZU;2-1
Abstract
The evaluation of the quality of data and their use in hazard and risk assessment as a systematic approach is described. Definitions are pro posed for reliability, relevance, and adequancy of data. Reliability i s differentiated into four categories. Criteria relating to internatio nal testing standards for categorizing reliability are developed. A sy stematic documentation of evaluating reliability especially for use in the IUCLID database is proposed. This approach is intended to harmoni ze data evaluation processes worldwide. It may help the expert in subs equent assessments and should increase the clarity of evaluation. (C) 1997 Academic Press.