ACTIVATION AND FUNCTION OF GAMMA-DELTA T-CELLS

T-cell receptor gene rearrangements in gamma delta T cells have been t he subject of intense molecular investigations. This year, much has be en learned about the mechanisms controlling this process. However, the specificity and function of gamma delta T cells still remains enigmat ic. The application of molecular technology including the availability of mutant mice lacking defined T-cell populations and immunologically relevant surface proteins is beginning to provide answers as well as some surprises.