MEETING REPORT - NEUTRALIZATION OF HIV-1

A Workshop on Neutralization of HIV-1: Technology and reagents for ana lysis of prophylactic vaccines clinical trials, sponsored by the Food and Drug Administration (FDA) and the Division of AIDS, National Insti tute of Allergy and Infectious Diseases (NIAID), National Institutes o f Health (NIH), was held on April 19-20, 1993, in Bethesda, Maryland. This workshop brought together researchers who are involved in the dev elopment, testing, and evaluation of HIV-1 prophylactic vaccines. The major objectives were (1) to discuss critically the different neutrali zation and binding assays that are currently used in the evaluation of immune sera; (2) to identify assays that will measure the ''most rele vant'' antibodies, which are likely to predict neutralization of prima ry isolates; and (3) to identify well-characterized reference reagents , which could be used to standardize neutralization assays used in lab oratories around the world.