AN ELECTRON-LUCENT REGION WITHIN THE VIRION DISTINGUISHES HIV-1 FROM HIV-2 AND SIMIAN IMMUNODEFICIENCY VIRUS

Authors
YU QC MATSUDA Z YU XF ITO S ESSEX M LEE TH
Citation
Qc. Yu et al., AN ELECTRON-LUCENT REGION WITHIN THE VIRION DISTINGUISHES HIV-1 FROM HIV-2 AND SIMIAN IMMUNODEFICIENCY VIRUS, AIDS research and human retroviruses, 10(6), 1994, pp. 757-761
Citations number
41
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
AIDS research and human retroviruses → ACNP
ISSN journal
08892229
Volume
10
Issue
6
Year of publication
1994
Pages
757 - 761
Database
ISI
SICI code
0889-2229(1994)10:6<757:AERWTV>2.0.ZU;2-6
Abstract
Ultrastructural comparisons of immature or budding particles of human inmunodeficiency virus (HIV) types 1 and 2 and simian immunodeficiency virus of macaques (SIVmac) revealed no significant difference between these genetically distinct, but related, viruses. However, a region e ncompassing the core of mature HIV-1 virions was found to be more elec tron lucent than that observed in HIV-2 and SIVmac. This ultrastructur al distinction cannot be attributed to HIV-1-specific vpu, HIV-2/SIV-s pecific vpx, or virion-associated vpr gene products.