Bobwhite quails (Colinus virginianus) were inoculated intratracheally,
intraperitoneally, or subcutaneously with Indiana C adenovirus at 1,
3, 6, or 9 weeks of age. Mortality rates were 33-100% in quails inocul
ated at 1 or 3 weeks of age and 0-10% in quails inoculated at 6 or 9 w
eeks of age. Gross and histologic lesions included necrotizing trachei
tis and bronchitis with pneumonia, necrotizing hepatitis and splenitis
, and lymphoid depletion of the bursa of Fabricius; these were consist
ent with quail bronchitis. Indiana C is highly pathogenic in bobwhite
quails and cannot be recommended as a vaccine to prevent quail bronchi
tis.